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Laboratory Medicine

Test Directory / Anti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies

Anti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies

Brown clotted serum, gel barrier

TestAnti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies
Common AbbreviationsCovid Spike, nMABs
Tube typeBrown clotted serum, gel barrier
Clinical IndicationThe Covid Spike test is intended for identifying eligible inpatients for neutralising monoclonal antibody therapy (Ronapreve). Criteria for testing and treating are on the Trust COVID Hub on the Intranet.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL
Special PrecautionsNo special requirements
StabilityStable for 3 days at 15-25°C, 14 days at 2-8°C, 3 months at -20 °C.
Turnaround TimeUrgent: 24 hours
LaboratoryYork and Scarborough
Reference IntervalInterpretative result provided: REACTIVE if antibody seropositive (?0.80 U/mL), NON-REACTIVE if antibody seronegative (<0.80 U/mL).
LimitationsIcterus: Presence of bilirubin in concentrations up to 66 mg/dL. Haemolysis: Presence of haemoglobin in concentrations up to 1000 mg/dL . Lipaemia: Presence of triglycerides in concentrations up to 2000 mg/dL . The assay is unaffected by biotin (?4912 nmol/L or ?1200ng/mL)
Notes Antibody seronegative results (non-reactive) for York or Scarborough inpatients will be telephoned to appropriate clinical teams immediately.
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