Laboratory Medicine
Test Directory / Anti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies
Anti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies
Brown clotted serum, gel barrier
| Test | Anti-SARS-CoV-2 Spike Protein Neutralising Monoclonal Antibodies |
|---|---|
| Common Abbreviations | Covid Spike, nMABs |
| Profile | NA |
| Tube type | Brown clotted serum, gel barrier |
| Clinical Indication | The Covid Spike test is intended for identifying eligible inpatients for neutralising monoclonal antibody therapy (Ronapreve). Criteria for testing and treating are on the Trust COVID Hub on the Intranet. |
| Specimen Type | Blood |
| Sample type | Serum |
| Minimum Volume | 0.5mL |
| Special Precautions | No special requirements |
| Stability | Stable for 3 days at 15-25°C, 14 days at 2-8°C, 3 months at -20 °C. |
| Turnaround Time | Urgent: 24 hours |
| Laboratory | York and Scarborough |
| Reference Interval | Interpretative result provided: REACTIVE if antibody seropositive (?0.80 U/mL), NON-REACTIVE if antibody seronegative (<0.80 U/mL). |
| Limitations | Icterus: Presence of bilirubin in concentrations up to 66 mg/dL. Haemolysis: Presence of haemoglobin in concentrations up to 1000 mg/dL . Lipaemia: Presence of triglycerides in concentrations up to 2000 mg/dL . The assay is unaffected by biotin (?4912 nmol/L or ?1200ng/mL) |
| Notes | Antibody seronegative results (non-reactive) for York or Scarborough inpatients will be telephoned to appropriate clinical teams immediately. |
