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Laboratory Medicine

Test Directory / Cryoglobulins


Blown clotted serum, gel barrier and EDTA

Common AbbreviationsCRYO
Tube typeBlown clotted serum, gel barrier and EDTA
Clinical IndicationA cryoglobulin is a serum protein that precipitates at temperatures lower than body temperature. Cryoglobulinaemia is characterized by the presence of cryoglobulins in the serum. Most cryoglobulins are polyclonal immunoglobulin complexes, but nearly half are monoclonal, usually IgM.
Specimen TypeBlood
Sample typeSerum and EDTA plasma
Minimum Volume2mL
Special PrecautionsThe phlebotomist should telephone Blood Sciences Specimen Reception to arrange delivery of a pre-warmed sample tube when a cryoglobulin is requested. A member of laboratory staff will then bring the pre-warmed sample tube into which the blood sample should be collected. The sample must be kept as near to 37°C as possible after collection and brought to the laboratory immediately.
Turnaround TimeInpatient: 2 weeks Outpatient/ GP: 2 weeks
Reference IntervalInterpretative result provided
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Invitation to attend the Trust’s Annual Members Meeting

Trust members and the general public are invited to find out more about their local hospitals by attending the Trust’s virtual Annual Members Meeting (AMM), incorporating the Annual General Meeting (AGM), on Tuesday 26 October 2021, between 11:00am-12:30pm.