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Laboratory Medicine

Test Directory / Estimated GFR (CKD-EPI creatinine equation)

Estimated GFR (CKD-EPI creatinine equation)

Brown clotted serum, gel barrier or orange lithium heparin

TestEstimated GFR (CKD-EPI creatinine equation)
Common AbbreviationseGFR (CKD-EPI)
ProfileUrea and Electrolytes
Tube typeBrown clotted serum, gel barrier
Clinical IndicationChronic Kidney Disease (CKD) is classified according to estimated GFR (eGFR) and urinary albumin:creatinine ratio (ACR) (NICE Glinical Guideline 182 (2014)). CKD describes abnormal kidney function / structure. It is common, frequently unrecognised and often exists together with other conditions (such as CVD and diabetes). Moderate to severe CKD is also associated with an increased risk of other significant adverse outcomes such as acute kidney injury, falls, frailty and mortality. The risk of developing CKD increases with age. CKD can progress to end-stage kidney disease in a small but significant percentage of people.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability7 days at 2-25°C
Turnaround TimeUrgent: 2 hours Inpatient: 4 hours Outpatient/ GP: 24 hours
LaboratoryYork and Scarborough
Reference IntervalSee www.nice.org.uk/guidance/cg182
LimitationseGFR calculated by this method (CKD-EPIcreatinine) should be multiplied by 1.159 in people of African-Caribbean or African family origin to account for a higher muscle mass in these groups. In people with extremes of muscle mass - for example, in body builders, people who have had an amputation, are malnourished or with muscle wasting disorders - interpret eGFR with caution. (Reduced muscle mass will lead to overestimation and increased muscle mass will lead to underestimation of the GFR.) eGFR should be interpreted with caution in prenancy and in patients with oedema (serum creatinine values are affected by fluid status), and in patients of Asian or Chinese origin (calculated eGFR is less well validated in these ethnic groups). Advise people not to eat any meat in the 12 hours before having a blood test for eGFRcreatinine (ingestion of cooked meat causes transient increases in blood creatinine).
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