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Laboratory Medicine

Test Directory / Sex Hormone Binding Globulin

Sex Hormone Binding Globulin

Brown clotted serum, gel barrier

TestSex Hormone Binding Globulin
Common AbbreviationsSHBG
ProfileConsists of testosterone and SHBG
Tube typeBrown clotted serum, gel barrier
Clinical IndicationMeasurement of SHBG and testosterone levels enables the concentration of biologically active testosterone to be estimated. Testosterone circulates mainly in protein bound form, principally to SHBG, but also to albumin & cortisol binding globulin. Since variations in the carrier protein levels may affect the concentration of testosterone in circulation, SHBG levels are commonly measured as a supplement to total testosterone determinations. The Free Androgen Index (FAI), calculated as the ratio of total testosterone to SHBG in women, has proved a useful indicator of abnormal androgen status in conditions such as hirsutism.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability 5 days at 20 - 25°C, 7 days at 2 - 8°C and 12 months at -20°C
Turnaround TimeInpatient: 48 hours Outpatient/ GP: 48 hours
LaboratoryYork
Reference IntervalMale 20 - 49 years: 18.3 - 54.1 nmol/L Male ?50 years: 20.6 - 76.7 nmol/L Female 20 - 49 years: 32.4 - 128 nmol/L Female ? 50 years: 27.1 - 128 nmol/L (Quoted by the manufacturer)
LimitationsAnalysis should not be performed on haemolysed, icteric or lipaemic samples. No interference was observed from rheumatoid factors up to a concentration of 1200 IU/mL. The assay is unaffected by biotin < 287 nmol/L or < 70 ng/mL. In rare cases, high titres of antibodies to analyte specific antibodies, streptavidin or ruthenium can occur. Samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration. In vitro tests were performed on 16 commonly used pharmaceuticals. No interference with the assay was found
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Invitation to attend the Trust’s Annual Members Meeting

Trust members and the general public are invited to find out more about their local hospitals by attending the Trust’s virtual Annual Members Meeting (AMM), incorporating the Annual General Meeting (AGM), on Tuesday 26 October 2021, between 11:00am-12:30pm.