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Laboratory Medicine

Test Directory / Angiotensin Converting Enzyme

Angiotensin Converting Enzyme

Brown clotted serum, gel barrier

TestAngiotensin Converting Enzyme
Common AbbreviationsACE
Tube typeBrown clotted serum, gel barrier
Clinical IndicationSerum ACE levels are increased in at least 60% of patients with active Sarcoidosis and in about 20% of patients with the disease on steroid therapy. Serum ACE levels increase with the degree of sarcoid involvement and levels are useful for monitoring the condition. The levels increase with active disease and decrease with remission.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability1 month at 2-8°C
Turnaround TimeInpatient: 4 days Outpatient/ GP: 4 days
Reference IntervalAdult (>18 years) = 20-70 U/L Child (<18 years) = 29-112 U/L Reference range updated February 2019 - New Buhlman ACE assay ranges applied.
LimitationsThe assay should not be performed on grossly haemolysed samples. Plasma samples using chelators (EDTA, Oxalate etc) are unsuitable for this assay. Upon administration of angiotensin converting enzyme-inhibitory drugs, such as Captopril (used for treating hypertension), serum ACE activity is markedly reduced but levels usually return to normal in ~12 hours.
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