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Laboratory Medicine

Test Directory / Creatine Kinase

Creatine Kinase

Brown clotted serum, gel barrier

TestCreatine Kinase
Common AbbreviationsCK
Tube typeBrown clotted serum, gel barrier
Clinical IndicationMeasurements of CK are primarily used in the diagnosis and treatment of myocardial infarction as well as being the most sensitive indicator of muscle damage. CK is increased whenever there is necrosis or regeneration of muscle and is therefore elevated in most myopathies such as Duchenne-muscular dystrophy and in conditions associated with muscle necrosis such as rhabdomyolysis. Total CK can also be increased in Reyes syndrome.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability2 days at 20-25°C and 7 days at 2-8°C
Turnaround TimeUrgent: 2 hours Inpatient: 4 hours Outpatient/ GP: 24 hours
LaboratoryYork and Scarborough
Reference IntervalFemale: 25 - 200 IU/L Male: 40 - 320 IU/L (Recommended by Pathology Harmonisation Reference Group)
LimitationsHaemolysis interferes with the measurement of CK. Therefore haemolysed samples are not suitable for analysis. Hydroxocobalamin and Cyanokit (cyanide antidote) may cause interference.
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