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Laboratory Medicine

Test Directory / Cyclosporin



Common AbbreviationsCYC
Tube typeEDTA
Clinical IndicationUsed in the monitoring of immunosuppressant therapy.
Specimen TypeBlood
Sample typeEDTA whole blood
Minimum Volume0.5mL
Special PrecautionsNo special requirements
Stability 5 days at 15 - 25°C or 7 days at 2 - 8°C or 6 months at -20°C
Turnaround Time4 days
Reference IntervalNo firm therapeutic range exists for cyclosporine in whole blood. The complexity of the clinical state, individual differences in sensitivity to immunosuppressive and nephrotoxic effects of cyclosporine, coadministration of other immunosuppressants, type of transplant, time post-transplant, and a number of other factors contribute to different requirements for optimal blood levels of cyclosporine. Individual cyclosporine values cannot be used as the sole indicator for making changes in the treatment regimen. Each patient should be thoroughly evaluated clinically before treatment adjustments are made, and each assay user must establish his or her ranges based on clinical experience.
Limitations Icteric or lipaemic samples should not be analysed. The assay is unaffected by biotin (< 123 nmol/L or < 30 ng/mL) Samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration. In rare cases, interference due to extremely high titers of antibodies to analyte specific antibodies, streptavidin or ruthenium can occur. In vitro tests were performed by Roche on 16 commonly used pharmaceuticals. No interference with the assay was found. In addition, several special drugs were tested. No interference with the assay was found.
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