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Laboratory Medicine

Test Directory / HDL Cholesterol

HDL Cholesterol

Brown clotted serum, gel barrier or orange lithium heparin

TestHDL Cholesterol
Common AbbreviationsHDL
ProfileLipids
Tube typeBrown clotted serum, gel barrier or orange lithium heparin
Clinical IndicationApproximately 25% of total serum cholesterol is transported in the HDL fraction. Numerous studies have demonstrated a strong inverse association between HDL – cholesterol and the incidence of coronary heart disease. It has been proposed that the uptake and transport of cholesterol from peripheral tissue to the liver acts as a protective factor against the development of atheroschlerotic plaques. Determination of HDL cholesterol is therefore essential for the interpretation of individual cholesterol determinations. Low HDL is a risk factor independent of total cholesterol and is highly predictive of coronary heart disease.
Specimen TypeBlood
Sample typeSerum or plasma
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability7 days at 2-25°C
Turnaround TimeInpatient: 4 hours Outpatient/ GP: 24 hours
LaboratoryYork and Scarborough
Reference IntervalFemale: >1.1 mmol/L Male: >0.9 mmol/L (Recommended by Joint British Society Guidelines)
LimitationsGrossly haemolysed, lipaemic or icteric samples are not suitable for analysis. Methimazole (antithyroid) can give falsely low results if administered before/ during venepuncture. N-acetyl cysteine / NAPQI (paracetamol overdose) can give falsely low results.
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Trust members and the general public are invited to find out more about their local hospitals by attending the Trust’s virtual Annual Members Meeting (AMM), incorporating the Annual General Meeting (AGM), on Tuesday 26 October 2021, between 11:00am-12:30pm.