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Laboratory Medicine

Test Directory / Progesterone

Progesterone

Brown clotted serum, gel barrier

TestProgesterone
Common AbbreviationsPRG
ProfileNA
Tube typeBrown clotted serum, gel barrier
Clinical IndicationClinical evaluation of progesterone confirms ovulation and normal luteal function in nonpregnant women. Inadequate progesterone production by the corpus luteum may indicate luteal phase deficiency (LPD), which is associated with infertility and early miscarriage. Women using oral contraceptives have suppressed progesterone levels.
Specimen TypeBlood
Sample typeSerum
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability1 days at 20 - 25°C, 5 days at 2 - 8°C and 6 months at -20°C
Turnaround TimeInpatient: 48 hours Outpatient/ GP: 48 hours
LaboratoryYork
Reference IntervalFemale Luteal peak: 5.8 - 75.9 nmol/L (Quoted by the manufacturer)
LimitationsAnalysis should not be performed on haemolysed, icteric or lipaemic samples. Visibly turbid samples give a false low result. The assay is unaffected by biotin < 123 nmol/L or < 30 ng/mL. No interference was observed from rheumatoid factors up to a concentration of 1200 IU/mL. No interference was observed from IgG < 7.0 g/dL; IgA < 0.4 g/dL; IgM < 1.0 g/dL Samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration. In vitro tests were performed on 16 commonly used pharmaceuticals. No interference with the assay was found. In addition, clomiphene citrate was tested. No interference was found. In rare cases, interference due to extremely high titres of antibodies to analyte specific antibodies, streptavidin or ruthenium can occur.
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