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Laboratory Medicine

Test Directory / Urine Metanephrines

Urine Metanephrines

24 Hour Urine Container (plain or acidified)

TestUrine Metanephrines
Common AbbreviationsUMET, METS, URINE NA/NMA
ProfileN/A
Tube type24 Hour Urine Container (plain or acidified)
Clinical IndicationInvestigation of suspected phaeochromocytoma. Urine metanephrines are generally used for screening (e.g. in uncontrolled or accelerated hypertension), whereas plasma metanephrines are preferred in patients with a high pre-test probability of phaeochromocytoma (e.g. visible adrenal mass or genetic predisposition) .
Specimen TypeUrine
Sample type24 Hour Urine
Minimum Volume5mL
Special PrecautionsSamples collected into a plain container should be delivered to the laboratory as soon as possible for acidification.
Stability Samples stable for 7 days at room temperature
Turnaround Time7 days at room temperature
LaboratoryHull Royal Infirmary Anlaby Road Hull HU3 2JZ 01482 607753
Reference IntervalUrine Normetanephrine: <3.5µmol/24hrs Urine Metanephrine: <1.5µmol/24hrs
LimitationsPatients investigated for possible phaeochromocytoma may well already be prescribed beta-blockers such as atenolol, metoprolol or propranolol. These can give false positive increases in urine metanephrines. Of note such false positive results are not observed when analysing plasma metanephrines. Other drugs which may give rise to false positive results in urine metanephrines include: • alpha blockers including phenoxybenzamine, doxazosin and prazosin • Tricyclic anti-depressants such as amitriptyline, amoxapine and nortriptyline • Calcium channel blockers such as amlodipine
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