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Laboratory Medicine

Test Directory / Valproic Acid

Valproic Acid

Brown clotted serum, gel barrier or lithium heparin

TestValproic Acid
Common AbbreviationsVAL
Tube typeBrown clotted serum, gel barrier or lithium heparin
Clinical IndicationValproate is an anti-convulsant medication that is primarily used for the treatment of primary and secondary generalised seizures, but it is also effective against absence seizures. It has the fewest side effects of all the widely used anti-epileptic agents. The most common side effects are nausea and vomiting. Serum valproate levels are only useful to check compliance or possible overdose and are of little use for therapeutic monitoring (clinical effects are more reliable).
Specimen TypeBlood
Sample typeSerum or plasma
Minimum Volume0.5mL If requesting more than 10 tests please send an additional brown clotted serum sample.
Special PrecautionsNo special requirements
Stability2 days at 20-25°C and 7 days at 2 - 8°C
Turnaround TimeInpatient: 6 hours Outpatient/ GP: 24 hours
Reference IntervalTherapeutic Range: 50 - 100 mg/L (Quoted by the manufacturer)
LimitationsSamples containing antibodies to E. coli ?-galactosidase may result in artificially high results which will not fit the clinical profile. The incidence of patients having such antibodies is extremely low. As with any assay employing mouse antibodies, the possibility exists for interference by human anti-mouse antibodies (HAMA) in the sample, which could cause falsely elevated results.
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