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Laboratory Medicine

Test Directory / Thrombin Time (TT)

Thrombin Time (TT)

Citrate Plasma

TestThrombin Time (TT)
Common AbbreviationsTT, TCT
ProfileIf required as part of a Thrombophilia Screen Antithrombin (AT), Protein C (PC), Protein S (PS) Thrombin Time (TT), Factor V Leiden (FVL), Prothrombin Gene Mutation (F2G), Lupus Inhibitor (LIS), Anticardiolipin (ACA), Coagulation Screen (CLS)
Clinical IndicationThe thrombin time measures the conversion of fibrinogen to fibrin after the addition of thrombin to plasma. Thrombin enzymatically cleaves fibrinopeptides A and B from the alpha and beta chains of fibrinogen, allowing for polymerization in fibrin. The thrombin time test will be prolonged in Disseminated Intravascular Coagulation (DIC), thrombin inhibitors (heparin, Dabigatran), in the presence of low levels (typically < 0.7-1 g/L) of fibrinogen and in structurally abnormal fibrinogen (dysfibrinogenaemia). Additionally, elevated levels of fibrinogen, fibrin degradation products (FDP) or the presence of paraproteins may prolong the thrombin time.
Specimen TypeBlood
Sample TypeCitrated Plasma (& Brown clotted serum, gel barrier if part of a thrombophilia screen)
Minimum Volume1 x 3 mL (adult)
Special Precautions
Stability4 - 6 hrs
Turnaround Time2 hours (urgent) - call lab prior. 4-6 weeks (routine)
LaboratoryYork and Scarborough Hospital
Reference IntervalIssued with final report
LimitationsA normal thrombin time excludes the presence of a clinically significant Dabigatran level.
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