Skip to content

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Find out more here. Hide this message

Laboratory Medicine

Test Directory / Anti-Histone Antibody

Anti-Histone Antibody

Brown clotted serum, gel barrier

TestAnti-Histone Antibody
Common AbbreviationsAHIST
Clinical IndicationHistones are basic proteins which bind to DNA within the nuclei of cells. Anti-histone antibodies are found in patients with SLE and patients with DIL. In SLE, anti-histone antibodies do not provide any better diagnostic information than DNA and anti-nuclear antibodies but in drug induced lupus, a typical antibody profile consists of anti-nuclear antibodies, anti-histone antibodies but rarely dsDNA antibodies and extractable nuclear antibodies. Drugs implicated in DIL include hydralazine, procainamide and isoniazid.
Specimen TypeBlood
Sample TypeSerum
Minimum Volume2 mL
Special PrecautionsNo special requirements
StabilityContact Referral Laboratory
Turnaround Time3 weeks
Laboratory Department of Immunology Northern General Hospital P O Box 894 Sheffield S5 7YT
Reference IntervalContact Referral Laboratory
LimitationsContact Referral Laboratory
Looking down a long bright hospital corridor with treatment rooms on the left and windows on the right. At the bottom of the corridor is one member of staff in a blue nursing uniform

Our Hospitals

Logo on blue with swoosh


Chinese Poland

View all languages >

Patients Know Best

York and Scarborough Teaching Hospitals NHS Foundation Trust is now offering patients the opportunity to sign up to our new online service that gives you secure access to your health record from any smartphone, tablet or computer. It’s designed to improve your patient experience and access to NHS services and information. The service is provided in partnership with Patients Know Best (PKB).  Further information can be found on our website, including frequently asked questions.