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Laboratory Medicine

Test Directory / Anti-Histone Antibody

Anti-Histone Antibody

Brown clotted serum, gel barrier

TestAnti-Histone Antibody
Common AbbreviationsAHIST
ProfileN/A
Clinical IndicationHistones are basic proteins which bind to DNA within the nuclei of cells. Anti-histone antibodies are found in patients with SLE and patients with DIL. In SLE, anti-histone antibodies do not provide any better diagnostic information than DNA and anti-nuclear antibodies but in drug induced lupus, a typical antibody profile consists of anti-nuclear antibodies, anti-histone antibodies but rarely dsDNA antibodies and extractable nuclear antibodies. Drugs implicated in DIL include hydralazine, procainamide and isoniazid.
Specimen TypeBlood
Sample TypeSerum
Minimum Volume2 mL
Special PrecautionsNo special requirements
StabilityContact Referral Laboratory
Turnaround Time3 weeks
Laboratory Department of Immunology Northern General Hospital P O Box 894 Sheffield S5 7YT
Reference IntervalContact Referral Laboratory
LimitationsContact Referral Laboratory
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