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Laboratory Medicine

Test Directory / Diabetes Autoantibodies

Diabetes Autoantibodies

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TestDiabetes Autoantibodies
Common AbbreviationsDAA/ GAD/ IA2/ ZnT8
ProfileAnti-Tyrosine phosphatase-like insulinoma antigen 2 (IA-2/IA2) antibodies Zinc Transporter 8 (ZnT8) islet autoantibodies Glutamic Acid Decarboxylase (GAD) antibodies
Clinical IndicationAutoantibodies recognising the islet cell antigens glutamic acid decarboxylase (GAD 65), Zinc Transporter 8 (ZnT8) and the anti-tyrosine phosphatase-like insulinoma antigen 2 (IA-2) are present in up to 90% of newly diagnosed patients with type 1 diabetes. The prevalence of GAD, IA-2 and ZnT8 autoantibodies is less than 1% in GCK, HNF1A and HNF4A MODY, and testing for these autoantibodies close to diagnosis gives very good discrimination of Type 1 diabetes from MODY (McDonald et al 2011 Diabet Med 28:1028-1033)
Specimen TypeBlood
Sample TypeSerum
Minimum Volume0.5ml
Special PrecautionsNo special requirements
StabilityContact referral laboratory
Turnaround Time3 weeks
LaboratoryArea A2. Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter. EX2 5DW
Reference IntervalContact referral laboratory
LimitationsContact referral laboratory
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