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Laboratory Medicine

Test Directory / LGI1 and CASPR2 Antibodies (VGKC-complex antibodies)

LGI1 and CASPR2 Antibodies (VGKC-complex antibodies)

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TestLGI1 and CASPR2 Antibodies (VGKC-complex antibodies)
Common AbbreviationsVGKC
ProfileN/A
Clinical IndicationVGKC antibodies have recently been renamed VGKC-complex antibodies, as it is now recognised that the VGKCs are tightly complexed with other proteins and that the radioimmunoprecipitaion assay recognises the complexed proteins as well as the VGKCs themselves. The most common complex proteins discovered so far are LGI1 and CASPR2. However, as not all the complex proteins have been identified, we recommend testing for VGKC-complex antibodies as a first step.
Specimen TypeBlood
Sample TypeSerum
Minimum Volume1 mL
Special PrecautionsNo special requirements
StabilityContact Referral Laboratory
Turnaround Time3 weeks
LaboratoryImmunology Laboratory, Oxford University Hospitals NHSFT
Reference IntervalContact Referral Laboratory
LimitationsContact Referral Laboratory
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