Laboratory Medicine
Test Directory / Voltage gated Ca2+ Antibodies Also know as: Calcium channel antibodies, LEMS
Voltage gated Ca2+ Antibodies Also know as: Calcium channel antibodies, LEMS
Brown clotted serum, gel barrier
| Test | Voltage gated Ca2+ Antibodies Also know as: Calcium channel antibodies, LEMS |
|---|---|
| Common Abbreviations | VGCC |
| Profile | |
| Clinical Indication | The assay is positive in approximately 85% of patients with the Lambert Eaton myasthenic syndrome (with or without small cell lung carcinoma SCLC) and in about 30% of Cerebellar ataxia with SCLC. Calcium channel antibodies are rarely found in patients without myasthenic symptoms, except at low titre in a few cases with small cell lung cancer. This is because small cell lung cancers express this voltage gated calcium channel. |
| Specimen Type | Blood |
| Sample Type | Serum |
| Minimum Volume | 1 mL |
| Special Precautions | No special requirements |
| Stability | Contact Referral Laboratory |
| Turnaround Time | 4 weeks |
| Laboratory | Immunology Laboratory, Oxford University Hospitals NHSFT |
| Reference Interval | Contact Referral Laboratory |
| Limitations | Contact Referral Laboratory |
