Laboratory Medicine
Test Directory / LGI1 and CASPR2 Antibodies (VGKC-complex antibodies)
LGI1 and CASPR2 Antibodies (VGKC-complex antibodies)
Brown clotted serum, gel barrier
| Test | LGI1 and CASPR2 Antibodies (VGKC-complex antibodies) |
|---|---|
| Common Abbreviations | VGKC |
| Profile | N/A |
| Clinical Indication | VGKC antibodies have recently been renamed VGKC-complex antibodies, as it is now recognised that the VGKCs are tightly complexed with other proteins and that the radioimmunoprecipitaion assay recognises the complexed proteins as well as the VGKCs themselves. The most common complex proteins discovered so far are LGI1 and CASPR2. However, as not all the complex proteins have been identified, we recommend testing for VGKC-complex antibodies as a first step. |
| Specimen Type | Blood |
| Sample Type | Serum |
| Minimum Volume | 1 mL |
| Special Precautions | No special requirements |
| Stability | Contact Referral Laboratory |
| Turnaround Time | 3 weeks |
| Laboratory | Immunology Laboratory, Oxford University Hospitals NHSFT |
| Reference Interval | Contact Referral Laboratory |
| Limitations | Contact Referral Laboratory |
