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Laboratory Medicine

Test Directory / Heparin Induced Thrombocytopenia (HIT-IgG) Assay

Heparin Induced Thrombocytopenia (HIT-IgG) Assay

Brown clotted serum, gel barrier

TestHeparin Induced Thrombocytopenia (HIT-IgG) Assay
Common AbbreviationsHIT, HIT-IgG(PF4-H)
Clinical IndicationThe HIT screen test combined with a pre-test probability scoring system, known as ‘4Ts’ is a useful aid in the management of HIT suspected patients. A low probability combined with a negative HIT result can exclude the presence of HIT and continue heparin therapy. A weak positivity for the PF4/heparin complex antibodies may indicate that the antibodies are non-platelet activating, while a strong positivity may indicate a higher risk of HIT.
Specimen TypeBlood
Sample TypeBrown clotted serum, gel barrier
Minimum Volume 0.5 - 1.0 mL
Special PrecautionsRefer to Trust policy.
Stability2 hours
Turnaround Time1 hour
LaboratoryYork Hospital
Reference IntervalReference range printed on final report.
LimitationsA positive sample for Rheumatoid Factor may cause a falsely raised HIT IgG levels. Although a positive reaction may indicate the presence of a heparin-associated antibody, the detection of antibodies DOES NOT CONFIRM the diagnosis of heparin-induced thrombocytopenia (HIT), as some patients may have naturally occurring antibodies to PF4.
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