Laboratory Medicine
Test Directory / ADAMTS-13 (vWF Cleaving Protease)
ADAMTS-13 (vWF Cleaving Protease)
Citrate Plasma
| Test | ADAMTS-13 (vWF Cleaving Protease) |
|---|---|
| Common Abbreviations | |
| Profile | ADAMTS-13 (vWF Cleaving Protease) |
| Clinical Indication | ADAMTS-13 is an enzyme (vWF-cleaving protease) that specifically cleaves unusually large vWF multimers (ULvWF) which induce platelet thrombus formation under high shear stress. If the activity is lowered, ULvWF may accumulate within the blood causing thrombosis due to platelet aggregation, which in turn may lead to Thrombotic Thrombocytopenic Purpura (TTP). |
| Specimen Type | Blood |
| Sample Type | Citrate plasma |
| Minimum Volume | 2 x 3mL (adult) 2 x 1mL (paed) (citrated plasma must be filled to bottle line) |
| Special Precautions | Request must be authorised by a Haematology Consultant/Registrar |
| Stability | 48hrs |
| Turnaround Time | 24 hours (urgent), 2 weeks (routine) |
| Laboratory | Royal Hallamshire Hospital, Sheffield |
| Reference Interval | Reference range printed on final report. |
| Limitations | N/A |
| Additional Information |
