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Laboratory Medicine

General Information / Advice for requesters - Clinical Biochemistry

Please find information by clicking on the links below:

Advice Regarding Test Requesting and Result Interpretation:

ALLERGY TESTING - How to diagnose allergy in adults in primary care

B12 - see HAEMATINICS

BIOTIN- Biotin interference in Roche-manufactured immunoassays

BNP - Use of natriuretic peptides in the management of suspected heart failure

CALPROTECTIN

- The York faecal calprotectin care pathway for GPs 

 - Faecal calprotectin guidance for patients being managed in secondary care

CORTISOL - Diagnosis of Cushings Syndrome

CHLORIDE – Guidance for interpreting chloride results

CREATINE KINASE - Causes of Elevated CK

CRP - See INFLAMMATORY MARKERS

CUSHINGS SYNDROME - See CORTISOL

DIABETES - see HBA1C

ESR - See INFLAMMATORY MARKERS

ESTRADIOL – See OESTRADIOL

FAECAL CALPROTECTIN - See CALPROTECTIN

FERRITIN (high) - Investigation of elevated ferritin *Updated Aug 2022*

FERRITIN (low) See HAEMATINICS

FOLATE - See HAEMATINCS

FREE LIGHT CHAINS – Guidance for interpreting free light chain results 

FSH - Menopause investigation and laboratory testing

HAEMATINICS - Guidance for primary care on interpretation of haematinics (B12, folate and ferritin) 

HBA1C (diagnosis of diabetes)Guidance for when HbA1c is not suitable for diagnosis of diabetes

HBA1C (monitoring of diabetes)Guidance for when HbA1c is not suitable for monitoring diabetes

HEART FAILURE - See BNP

HYPERKALAEMIA - See POTASSIUM

HYPONATRAEMIA - See SODIUM

HYPOMAGNESAEMIA - See MAGNESIUM

HYPOPHOSPHATAEMIA - See PHOSPHATE

IMMUNOGLOBULINS  - Guidance for investigation of low immunoglobulins

INFLAMMATORY MARKERS – Guidance for which test to use and when

LIVER BLOOD TESTS / LIVER DISEASE - 

- Guidance for primary care on liver disease and liver blood tests 

- Reference Ranges for Liver Function Tests in Pregnancy 

MAGNESIUM - Guidance for assessment and management of hypomagnesaemia in primary care

MENOPAUSE - See FSH

METANEPHRINES (Urine) – Investigation of suspected phaeochromocytoma using 24h urine metanephrines 

MYELOMA/MGUS - See PARAPROTEINS

OSMOLALITY (Urine) - Guidance for investigation of polyuria / polydipsia *Updated Oct 22*

OESTRADIOLInterpreting serum oestradiol levels

PARAPROTEINS - Management of patients with paraprotein 

PHOSPHATE -

Information for Primary Care: Management of Hypophosphataemia  **new document Feb 2023**

Renal Tubular Reabsorption of Phosphate

POTASSIUM -

- Investigating and management of hyperkalaemia (high potassium) in primary care (adults) 

- Investigating and management of hypokalaemia (low potassium) in primary care (adults)

- Top tips for avoiding haemolysis

- Hyperkalaemia due to DELAYED CENTRIFUGATION 

- To enquire about obtaining a centrifuge for your surgery, please contact Carl Burkinshaw, Biochemistry Operational Manager (York and Scarborough): 01723 342028, carl.burkinshaw@york.nhs.uk

POLYURIA- see OSMOLALITY (Urine)

PROLACTIN - Investigation of hyperprolactinaemia

PV - See INFLAMMATORY MARKERS

Renal Tubular Reabsorption of Phosphate - See PHOSPHATE

SODIUM - Investigation and management of hyponatraemia in primary care (adults) 

THERAPEUTIC DRUGS - Sampling requirements for commonly requested therapeutic drugs

THYROID FUNCTION TESTS - Guidance for requesting and interpreting thyroid function tests (TFTs)

TRACE ELEMENTS (ZINC, SELENIUM, COPPER) - A guide to requesting trace elements for adults in primary care 

TROPONIN - Troponin testing in primary care

Information Regarding Service Delivery

2018 01: REPORTING PROBLEMS

Procedure for recording and reporting sample quality problems

2019 03: INSULIN LIKE GROWTH FACTOR (IGF-1)

Reference Ranges

2019 04: CKD-EPI

Use of the CKD-EPI equation (NICE guideline 182)

 

Sample Collection and Testing Protocols

Aldosterone Renin Ratio

Urine Collection Procedure for 24 hour urine 

Glucose Tolerance Test 

Short Synacthen Test

Overnight Dexamethasone Suppression Test

Clinical Biochemistry Archived User Communications 

Archived Communications


Web Page 26 Last Updated: 22/03/2023

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